Desperately Seeking Susan For fans the film. Starring Madonna, Rosanna Arquette, Aidan Quinn, Mark Blum, Laurie Metcalf, and Robert Joy. Susan corresponses her boyfriend through the personal ads, unaware that bored suburban housewife Roberta reads them all, fascinated. When Roberta gets clunked on the head and is mistaken for Susan, she cannot remember not being Susan at all, as everything about her sounds familiar but fuzzy. This film helped launch the Madonna explosion and has remained one of her most popular. It is also notable for one of her biggest hits: "Into the Groove".